p85β regulates autophagic degradation of AXL to activate oncogenic signaling

PIK3R2 encodes the p85β regulatory subunit of phosphatidylinositol 3-kinase and is frequently amplified in cancers. The signaling mechanism and therapeutic implication of p85β are poorly understood. Here we report that p85β upregulates the protein level of the receptor tyrosine kinase AXL to induce...

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Detalles Bibliográficos
Autores principales: Rao, Ling, Mak, Victor C. Y., Zhou, Yuan, Zhang, Dong, Li, Xinran, Fung, Chloe C. Y., Sharma, Rakesh, Gu, Chao, Lu, Yiling, Tipoe, George L., Cheung, Annie N. Y., Mills, Gordon B., Cheung, Lydia W. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210311/
https://www.ncbi.nlm.nih.gov/pubmed/32385243
http://dx.doi.org/10.1038/s41467-020-16061-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210311/
https://www.ncbi.nlm.nih.gov/pubmed/32385243
http://dx.doi.org/10.1038/s41467-020-16061-7

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