Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus

Tumor-targeting oncolytic viruses such as vaccinia virus (VV) are attractive cancer therapeutic agents that act through multiple mechanisms to provoke both tumor lysis and anti-tumor immune responses. However, delivery of these agents remains restricted to intra-tumoral administration, which prevent...

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Detalles Bibliográficos
Autores principales: Ferguson, Mark S., Chard Dunmall, Louisa S., Gangeswaran, Rathi, Marelli, Giulia, Tysome, James R., Burns, Emily, Whitehead, Maria A., Aksoy, Ezra, Alusi, Ghassan, Hiley, Crispin, Ahmed, Jay, Vanhaesebroeck, Bart, Lemoine, Nicholas R., Wang, Yaohe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210704/
https://www.ncbi.nlm.nih.gov/pubmed/32145202
http://dx.doi.org/10.1016/j.ymthe.2020.02.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210704/
https://www.ncbi.nlm.nih.gov/pubmed/32145202
http://dx.doi.org/10.1016/j.ymthe.2020.02.017

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