Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms

Bruton’s tyrosine kinase (Btk) is critical for B-cell maturation and activation. Btk loss-of-function mutations cause human X-linked agammaglobulinemia (XLA). In contrast, Btk signaling sustains growth of several B-cell neoplasms which may be treated with tyrosine kinase inhibitors (TKIs). Here, we...

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Detalles Bibliográficos
Autores principales: Duarte, Daniel P., Lamontanara, Allan J., La Sala, Giuseppina, Jeong, Sukyo, Sohn, Yoo-Kyoung, Panjkovich, Alejandro, Georgeon, Sandrine, Kükenshöner, Tim, Marcaida, Maria J., Pojer, Florence, De Vivo, Marco, Svergun, Dmitri, Kim, Hak-Sung, Dal Peraro, Matteo, Hantschel, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210950/
https://www.ncbi.nlm.nih.gov/pubmed/32385234
http://dx.doi.org/10.1038/s41467-020-16128-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210950/
https://www.ncbi.nlm.nih.gov/pubmed/32385234
http://dx.doi.org/10.1038/s41467-020-16128-5

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