A VHH-Based Anti-MUC1 Chimeric Antigen Receptor for Specific Retargeting of Human Primary T Cells to MUC1-Positive Cancer Cells

OBJECTIVE: Immunotherapy with redirected T cells that express a chimeric antigen receptor (CAR) is a promising prospect in cancer treatment. Most CARs use murine-derived single-chain variable fragments (scFvs) as an antigen targeting moiety, which may lead to host immunogenic responses and engineere...

Descripción completa

Detalles Bibliográficos
Autores principales: Rajabzadeh, Alireza, Rahbarizadeh, Fatemeh, Ahmadvand, Davoud, Kabir Salmani, Maryam, Hamidieh, Amir Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211288/
https://www.ncbi.nlm.nih.gov/pubmed/32347044
http://dx.doi.org/10.22074/cellj.2021.6917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211288/
https://www.ncbi.nlm.nih.gov/pubmed/32347044
http://dx.doi.org/10.22074/cellj.2021.6917

Ejemplares similares