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A VHH-Based Anti-MUC1 Chimeric Antigen Receptor for Specific Retargeting of Human Primary T Cells to MUC1-Positive Cancer Cells

OBJECTIVE: Immunotherapy with redirected T cells that express a chimeric antigen receptor (CAR) is a promising prospect in cancer treatment. Most CARs use murine-derived single-chain variable fragments (scFvs) as an antigen targeting moiety, which may lead to host immunogenic responses and engineere...

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Detalles Bibliográficos
Autores principales:	Rajabzadeh, Alireza, Rahbarizadeh, Fatemeh, Ahmadvand, Davoud, Kabir Salmani, Maryam, Hamidieh, Amir Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royan Institute 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211288/ https://www.ncbi.nlm.nih.gov/pubmed/32347044 http://dx.doi.org/10.22074/cellj.2021.6917

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