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Reversal of hyperactive subthalamic circuits differentially mitigates pain hypersensitivity phenotypes in parkinsonian mice

Although pain is a prevalent nonmotor symptom in Parkinson’s disease (PD), it is undertreated, in part because of our limited understanding of the underlying mechanisms. Considering that the basal ganglia are implicated in pain sensation, and that their synaptic outputs are controlled by the subthal...

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Detalles Bibliográficos
Autores principales: Luan, Yiwen, Tang, Dongliang, Wu, Haichuan, Gu, Weixin, Wu, Yuqing, Cao, Jun-Li, Xiao, Cheng, Zhou, Chunyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211985/
https://www.ncbi.nlm.nih.gov/pubmed/32312820
http://dx.doi.org/10.1073/pnas.1916263117