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A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes
Genetic variants within complement factor H (CFH), a major alternative complement pathway regulator, are associated with the development of age-related macular degeneration (AMD) and other complementopathies. This is explained with the reduced binding of CFH or its splice variant factor H-like prote...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211993/ https://www.ncbi.nlm.nih.gov/pubmed/32321835 http://dx.doi.org/10.1073/pnas.1913970117 |