A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes

Genetic variants within complement factor H (CFH), a major alternative complement pathway regulator, are associated with the development of age-related macular degeneration (AMD) and other complementopathies. This is explained with the reduced binding of CFH or its splice variant factor H-like prote...

Descripción completa

Detalles Bibliográficos
Autores principales: Alic, Lejla, Papac-Milicevic, Nikolina, Czamara, Darina, Rudnick, Ramona B., Ozsvar-Kozma, Maria, Hartmann, Andrea, Gurbisz, Michael, Hoermann, Gregor, Haslinger-Hutter, Stefanie, Zipfel, Peter F., Skerka, Christine, Binder, Elisabeth B., Binder, Christoph J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211993/
https://www.ncbi.nlm.nih.gov/pubmed/32321835
http://dx.doi.org/10.1073/pnas.1913970117

Ejemplares similares

Ejemplares similares