Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism

Synaptic activity in neurons leads to the rapid activation of genes involved in mammalian behavior. ATP-dependent chromatin remodelers such as the BAF complex contribute to these responses and are generally thought to activate transcription. However, the mechanisms keeping such “early activation” ge...

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Detalles Bibliográficos
Autores principales: Wenderski, Wendy, Wang, Lu, Krokhotin, Andrey, Walsh, Jessica J., Li, Hongjie, Shoji, Hirotaka, Ghosh, Shereen, George, Renee D., Miller, Erik L., Elias, Laura, Gillespie, Mark A., Son, Esther Y., Staahl, Brett T., Baek, Seung Tae, Stanley, Valentina, Moncada, Cynthia, Shipony, Zohar, Linker, Sara B., Marchetto, Maria C. N., Gage, Fred H., Chen, Dillon, Sultan, Tipu, Zaki, Maha S., Ranish, Jeffrey A., Miyakawa, Tsuyoshi, Luo, Liqun, Malenka, Robert C., Crabtree, Gerald R., Gleeson, Joseph G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211998/
https://www.ncbi.nlm.nih.gov/pubmed/32312822
http://dx.doi.org/10.1073/pnas.1908238117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211998/
https://www.ncbi.nlm.nih.gov/pubmed/32312822
http://dx.doi.org/10.1073/pnas.1908238117

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