Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation

During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient(1,2). Despite its widespread use our understanding of t...

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Detalles Bibliográficos
Autores principales: Martin, Jack L., Costa, Ana S. H., Gruszczyk, Anja V., Beach, Timothy E., Allen, Fay M., Prag, Hiran A., Hinchy, Elizabeth C., Mahbubani, Krishnaa, Hamed, Mazin, Tronci, Laura, Nikitopoulou, Efterpi, James, Andrew M., Krieg, Thomas, Robinson, Alan J., Huang, Margaret H., Caldwell, Stuart T., Logan, Angela, Pala, Laura, Hartley, Richard C., Frezza, Christian, Saeb-Parsy, Kourosh, Murphy, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212038/
https://www.ncbi.nlm.nih.gov/pubmed/32395697
http://dx.doi.org/10.1038/s42255-019-0115-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212038/
https://www.ncbi.nlm.nih.gov/pubmed/32395697
http://dx.doi.org/10.1038/s42255-019-0115-y

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