Exosome-associated SUMOylation mutant AAV demonstrates improved ocular gene transfer efficiency in vivo

Exosome associated Adeno-associated virus (AAV) vectors have emerged as a promising tool in gene therapy. Recently, we elucidated the role of SUMOylation post-translational modification in AAV2 capsid and demonstrated that capsid modifications at SUMOylation sites, enhance vector transduction. The p...

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Detalles Bibliográficos
Autores principales: Maurya, Shubham, Jayandharan, Giridhara R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212041/
https://www.ncbi.nlm.nih.gov/pubmed/32302639
http://dx.doi.org/10.1016/j.virusres.2020.197966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212041/
https://www.ncbi.nlm.nih.gov/pubmed/32302639
http://dx.doi.org/10.1016/j.virusres.2020.197966

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