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Exosome-associated SUMOylation mutant AAV demonstrates improved ocular gene transfer efficiency in vivo
Exosome associated Adeno-associated virus (AAV) vectors have emerged as a promising tool in gene therapy. Recently, we elucidated the role of SUMOylation post-translational modification in AAV2 capsid and demonstrated that capsid modifications at SUMOylation sites, enhance vector transduction. The p...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212041/ https://www.ncbi.nlm.nih.gov/pubmed/32302639 http://dx.doi.org/10.1016/j.virusres.2020.197966 |