BCG-induced trained immunity: can it offer protection against COVID-19?

Bacillus Calmette–Guérin (BCG) vaccination has been reported to decrease susceptibility to respiratory tract infections, an effect proposed to be mediated by the general long-term boosting of innate immune mechanisms, also termed trained immunity. Here, we discuss the non-specific beneficial effects...

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Detalles Bibliográficos
Autores principales: O’Neill, Luke A. J., Netea, Mihai G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212510/
https://www.ncbi.nlm.nih.gov/pubmed/32393823
http://dx.doi.org/10.1038/s41577-020-0337-y
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author O’Neill, Luke A. J.
Netea, Mihai G.
author_facet O’Neill, Luke A. J.
Netea, Mihai G.
author_sort O’Neill, Luke A. J.
collection PubMed
description Bacillus Calmette–Guérin (BCG) vaccination has been reported to decrease susceptibility to respiratory tract infections, an effect proposed to be mediated by the general long-term boosting of innate immune mechanisms, also termed trained immunity. Here, we discuss the non-specific beneficial effects of BCG against viral infections and whether this vaccine may afford protection to COVID-19.
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spelling pubmed-72125102020-05-11 BCG-induced trained immunity: can it offer protection against COVID-19? O’Neill, Luke A. J. Netea, Mihai G. Nat Rev Immunol Comment Bacillus Calmette–Guérin (BCG) vaccination has been reported to decrease susceptibility to respiratory tract infections, an effect proposed to be mediated by the general long-term boosting of innate immune mechanisms, also termed trained immunity. Here, we discuss the non-specific beneficial effects of BCG against viral infections and whether this vaccine may afford protection to COVID-19. Nature Publishing Group UK 2020-05-11 2020 /pmc/articles/PMC7212510/ /pubmed/32393823 http://dx.doi.org/10.1038/s41577-020-0337-y Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
O’Neill, Luke A. J.
Netea, Mihai G.
BCG-induced trained immunity: can it offer protection against COVID-19?
title BCG-induced trained immunity: can it offer protection against COVID-19?
title_full BCG-induced trained immunity: can it offer protection against COVID-19?
title_fullStr BCG-induced trained immunity: can it offer protection against COVID-19?
title_full_unstemmed BCG-induced trained immunity: can it offer protection against COVID-19?
title_short BCG-induced trained immunity: can it offer protection against COVID-19?
title_sort bcg-induced trained immunity: can it offer protection against covid-19?
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212510/
https://www.ncbi.nlm.nih.gov/pubmed/32393823
http://dx.doi.org/10.1038/s41577-020-0337-y
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