Affinity-Selected Bicyclic Peptide G-Quadruplex Ligands Mimic a Protein-like Binding Mechanism

[Image: see text] The study of G-quadruplexes (G4s) in a cellular context has demonstrated links between these nucleic acid secondary structures, gene expression, and DNA replication. Ligands that bind to the G4 structure therefore present an excellent opportunity for influencing gene expression thr...

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Detalles Bibliográficos
Autores principales: Liu, Kim C., Röder, Konstantin, Mayer, Clemens, Adhikari, Santosh, Wales, David J., Balasubramanian, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212521/
https://www.ncbi.nlm.nih.gov/pubmed/32267689
http://dx.doi.org/10.1021/jacs.0c01879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212521/
https://www.ncbi.nlm.nih.gov/pubmed/32267689
http://dx.doi.org/10.1021/jacs.0c01879

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