α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species

Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient centrifugation and transiently transfected HEK 293T cell...

Descripción completa

Detalles Bibliográficos
Autores principales: Morgan, Sophie A., Lavenir, Isabelle, Fan, Juan, Masuda-Suzukake, Masami, Passarella, Daniela, DeTure, Michael A., Dickson, Dennis W., Ghetti, Bernardino, Goedert, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212628/
https://www.ncbi.nlm.nih.gov/pubmed/32209651
http://dx.doi.org/10.1074/jbc.RA119.012179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212628/
https://www.ncbi.nlm.nih.gov/pubmed/32209651
http://dx.doi.org/10.1074/jbc.RA119.012179

Ejemplares similares