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The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases
BACKGROUND: Lysosomes digest extracellular material from the endocytic pathway and intracellular material from the autophagic pathway. This process is performed by the resident hydrolytic enzymes activated by the highly acidic pH within the lysosomal lumen. Lysosome pH gradients are mainly maintaine...
Autores principales: | Song, Qiaoyun, Meng, Bo, Xu, Haidong, Mao, Zixu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212675/ https://www.ncbi.nlm.nih.gov/pubmed/32393395 http://dx.doi.org/10.1186/s40035-020-00196-0 |
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