Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal-Melphalan Prodrug for Glioblastoma Treatment

Glioblastoma (GBM) is the most frequent and aggressive primary tumor of the brain and averages a life expectancy in diagnosed patients of only 15 months. Hence, more effective therapies against this malignancy are urgently needed. Several diseases, including cancer, are featured by high levels of re...

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Detalles Bibliográficos
Autores principales: Oddone, Natalia, Boury, Frank, Garcion, Emmanuel, Grabrucker, Andreas M., Martinez, M. Carmen, Da Ros, Federica, Janaszewska, Anna, Forni, Flavio, Vandelli, Maria Angela, Tosi, Giovanni, Ruozi, Barbara, Duskey, Jason T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212708/
https://www.ncbi.nlm.nih.gov/pubmed/32425795
http://dx.doi.org/10.3389/fphar.2020.00574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212708/
https://www.ncbi.nlm.nih.gov/pubmed/32425795
http://dx.doi.org/10.3389/fphar.2020.00574

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