Investigation of the Inhibitory Effect of Simvastatin on the Metabolism of Lidocaine Both in vitro and in vivo

BACKGROUND: Lidocaine has cardiovascular and neurologic toxicity, which is dose-dependent. Due to CYP3A4-involved metabolism, lidocaine may be prone to drug–drug interactions. MATERIALS AND METHODS: Given statins have the possibility of combination with lidocaine in the clinic, we established in vit...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Ou-yang, Qiu-geng, Huang, Wan-li, Huang, Huan-le, Zhuang, Xin-lei, Lin, Qian-meng, Zeng, Da-li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212776/
https://www.ncbi.nlm.nih.gov/pubmed/32440099
http://dx.doi.org/10.2147/DDDT.S241022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212776/
https://www.ncbi.nlm.nih.gov/pubmed/32440099
http://dx.doi.org/10.2147/DDDT.S241022

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