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Investigation of the Inhibitory Effect of Simvastatin on the Metabolism of Lidocaine Both in vitro and in vivo

BACKGROUND: Lidocaine has cardiovascular and neurologic toxicity, which is dose-dependent. Due to CYP3A4-involved metabolism, lidocaine may be prone to drug–drug interactions. MATERIALS AND METHODS: Given statins have the possibility of combination with lidocaine in the clinic, we established in vit...

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Detalles Bibliográficos
Autores principales:	Wang, Ying, Ou-yang, Qiu-geng, Huang, Wan-li, Huang, Huan-le, Zhuang, Xin-lei, Lin, Qian-meng, Zeng, Da-li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212776/ https://www.ncbi.nlm.nih.gov/pubmed/32440099 http://dx.doi.org/10.2147/DDDT.S241022

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