Interferon-β exposure induces a fragile glioblastoma stem cell phenotype with a transcriptional profile of reduced migratory and MAPK pathway activity

BACKGROUND: Type I interferons (IFN-α/β) are cytokines that are typically expressed in response to double-stranded RNA associated with viral infections. Glioblastomas are the most common malignant primary brain tumors, characterized by an infiltrative growth pattern and prominent angiogenic activity...

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Detalles Bibliográficos
Autores principales: Lohmann, Birthe, Silginer, Manuela, Picard, Daniel, Schneider, Hannah, Remke, Marc, Roth, Patrick, Reifenberger, Guido, Weller, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212887/
https://www.ncbi.nlm.nih.gov/pubmed/32642697
http://dx.doi.org/10.1093/noajnl/vdaa043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212887/
https://www.ncbi.nlm.nih.gov/pubmed/32642697
http://dx.doi.org/10.1093/noajnl/vdaa043

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