Cargando…
Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome
The cardiac action potential is critical to the production of a synchronized heartbeat. This electrical impulse is governed by the intricate activity of cardiac ion channels, among them the cardiac voltage-gated potassium (K(v)) channels KCNQ1 and hERG as well as the voltage-gated sodium (Na(v)) cha...
Autores principales: | Brewer, Kathryn R., Kuenze, Georg, Vanoye, Carlos G., George, Alfred L., Meiler, Jens, Sanders, Charles R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212895/ https://www.ncbi.nlm.nih.gov/pubmed/32431610 http://dx.doi.org/10.3389/fphar.2020.00550 |
Ejemplares similares
-
Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations
por: Huang, Hui, et al.
Publicado: (2018) -
Upgraded molecular models of the human KCNQ1 potassium channel
por: Kuenze, Georg, et al.
Publicado: (2019) -
Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation
por: Kuenze, Georg, et al.
Publicado: (2020) -
Disease-linked supertrafficking of a potassium channel
por: Huang, Hui, et al.
Publicado: (2021) -
Predicting the functional impact of KCNQ1 variants with artificial neural networks
por: Phul, Saksham, et al.
Publicado: (2022)