BSCI-04. TARGETING TRIPLE-NEGATIVE BREAST CANCER BRAIN METASTASES WITH A RE-ENGINEERED LUPUS AUTOANTIBODY

An unusual lupus anti-DNA autoantibody, 3E10, has potential to be used against triple-negative breast cancer (TNBC) brain metastases. 3E10 penetrates live cell nuclei, inhibits DNA repair, and is selectively toxic to cancer cells with the PTEN and/or DNA-damage response (DDR)-deficiencies that are a...

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Detalles Bibliográficos
Autores principales: Zhang, Shenqi, May, Christopher, Shirali, Anupama, Dubljevic, Valentina, Campbell, James, Zhou, Jiangbing, Hansen, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213175/
http://dx.doi.org/10.1093/noajnl/vdz014.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213175/
http://dx.doi.org/10.1093/noajnl/vdz014.003

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