ET-05 PRECLINICAL STUDY OF AN ANTI-HUMAN TISSUE FACTOR ANTIBODY-DRUG CONJUGATE IN A MALIGNANT GLIOMA XENOGRAFT MODEL

Whereas macromolecules such as antibody hardly extravasate from normal blood vessels compared with low molecular agents, macromolecules leak from tumor vasculature because of the enhanced permeability. As a result, macromolecules selectively accumulate at tumor sites. We apply this phenomenon, known...

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Detalles Bibliográficos
Autores principales: Takashima, Hiroki, Manabe, Shino, Tsuji, Atsushi, Saga, Tsuneo, Tsumura, Ryo, Anzai, Takahiro, Koga, Yoshikatsu, Yasunaga, Masahiro, Kuroda, Jun-Ichiro, Mukasa, Akitake, Matsumura, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213193/
http://dx.doi.org/10.1093/noajnl/vdz039.039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213193/
http://dx.doi.org/10.1093/noajnl/vdz039.039

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