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Genetic algorithm-based personalized models of human cardiac action potential

We present a novel modification of genetic algorithm (GA) which determines personalized parameters of cardiomyocyte electrophysiology model based on set of experimental human action potential (AP) recorded at different heart rates. In order to find the steady state solution, the optimized algorithm...

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Detalles Bibliográficos
Autores principales: Smirnov, Dmitrii, Pikunov, Andrey, Syunyaev, Roman, Deviatiiarov, Ruslan, Gusev, Oleg, Aras, Kedar, Gams, Anna, Koppel, Aaron, Efimov, Igor R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213718/
https://www.ncbi.nlm.nih.gov/pubmed/32392258
http://dx.doi.org/10.1371/journal.pone.0231695