Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9

Multifunctional proteins are evolutionary puzzles: how do proteins evolve to satisfy multiple functional constraints? S100A9 is one such multifunctional protein. It potently amplifies inflammation via Toll-like receptor four and is antimicrobial as part of a heterocomplex with S100A8. These two func...

Descripción completa

Detalles Bibliográficos
Autores principales: Harman, Joseph L, Loes, Andrea N, Warren, Gus D, Heaphy, Maureen C, Lampi, Kirsten J, Harms, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213983/
https://www.ncbi.nlm.nih.gov/pubmed/32255429
http://dx.doi.org/10.7554/eLife.54100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213983/
https://www.ncbi.nlm.nih.gov/pubmed/32255429
http://dx.doi.org/10.7554/eLife.54100

Ejemplares similares