A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses

Malaria-071, a controlled human malaria infection trial, demonstrated that administration of three doses of RTS,S/AS01 malaria vaccine given at one-month intervals was inferior to a delayed fractional dose (DFD) schedule (62.5% vs 86.7% protection, respectively). To investigate the underlying immuno...

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Detalles Bibliográficos
Autores principales: Pallikkuth, Suresh, Chaudhury, Sidhartha, Lu, Pinyi, Pan, Li, Jongert, Erik, Wille-Reece, Ulrike, Pahwa, Savita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213985/
https://www.ncbi.nlm.nih.gov/pubmed/32342859
http://dx.doi.org/10.7554/eLife.51889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213985/
https://www.ncbi.nlm.nih.gov/pubmed/32342859
http://dx.doi.org/10.7554/eLife.51889

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