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A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses

Malaria-071, a controlled human malaria infection trial, demonstrated that administration of three doses of RTS,S/AS01 malaria vaccine given at one-month intervals was inferior to a delayed fractional dose (DFD) schedule (62.5% vs 86.7% protection, respectively). To investigate the underlying immuno...

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Detalles Bibliográficos
Autores principales:	Pallikkuth, Suresh, Chaudhury, Sidhartha, Lu, Pinyi, Pan, Li, Jongert, Erik, Wille-Reece, Ulrike, Pahwa, Savita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213985/ https://www.ncbi.nlm.nih.gov/pubmed/32342859 http://dx.doi.org/10.7554/eLife.51889

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