Reduced Sirtuin1 signalling exacerbates diabetic mice hindlimb ischaemia injury and inhibits the protective effect of a liver X receptor agonist

Diabetes mellitus causes endothelial dysfunction, which further exacerbates peripheral arterial disease (PAD). Improving endothelial function via reducing endothelial oxidative stress (OS) may be a promising therapy for diabetic PAD. Activation of liver X receptor (LXR) inhibits excessive OS and pro...

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Detalles Bibliográficos
Autores principales: Fan, Wensi, Zhang, Ran, Han, Dong, Jiang, Zhenhua, Li, Shuang, Zhang, Jibin, Li, Yanhua, Wang, Yabin, Cao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214142/
https://www.ncbi.nlm.nih.gov/pubmed/32286000
http://dx.doi.org/10.1111/jcmm.15201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214142/
https://www.ncbi.nlm.nih.gov/pubmed/32286000
http://dx.doi.org/10.1111/jcmm.15201

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