Characterization of a novel type III CRISPR-Cas effector provides new insights into the allosteric activation and suppression of the Cas10 DNase

Antiviral defense by type III CRISPR-Cas systems relies on two distinct activities of their effectors: the RNA-activated DNA cleavage and synthesis of cyclic oligoadenylate. Both activities are featured as indiscriminate nucleic acid cleavage and subjected to the spatiotemporal regulation. To yield...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Jinzhong, Feng, Mingxia, Zhang, Heping, She, Qunxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214462/
https://www.ncbi.nlm.nih.gov/pubmed/32411384
http://dx.doi.org/10.1038/s41421-020-0160-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214462/
https://www.ncbi.nlm.nih.gov/pubmed/32411384
http://dx.doi.org/10.1038/s41421-020-0160-4

Ejemplares similares