The therapeutic value of SC66 in human renal cell carcinoma cells

The PI3K-AKT-mTOR cascade is required for renal cell carcinoma (RCC) progression. SC66 is novel AKT inhibitor. We found that SC66 inhibited viability, proliferation, migration and invasion of RCC cell lines (786-O and A498) and patient-derived primary RCC cells. Although SC66blocked AKT-mTORC1/2 act...

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Detalles Bibliográficos
Autores principales: Xu, Ming, Wang, Yin, Zhou, Li-Na, Xu, Li-jun, Jin, Zhi-chang, Yang, Dong-rong, Chen, Min-bin, Zhu, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214466/
https://www.ncbi.nlm.nih.gov/pubmed/32393791
http://dx.doi.org/10.1038/s41419-020-2566-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214466/
https://www.ncbi.nlm.nih.gov/pubmed/32393791
http://dx.doi.org/10.1038/s41419-020-2566-1

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