Cargando…

The therapeutic value of SC66 in human renal cell carcinoma cells

The PI3K-AKT-mTOR cascade is required for renal cell carcinoma (RCC) progression. SC66 is novel AKT inhibitor. We found that SC66 inhibited viability, proliferation, migration and invasion of RCC cell lines (786-O and A498) and patient-derived primary RCC cells. Although SC66blocked AKT-mTORC1/2 act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Ming, Wang, Yin, Zhou, Li-Na, Xu, Li-jun, Jin, Zhi-chang, Yang, Dong-rong, Chen, Min-bin, Zhu, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214466/ https://www.ncbi.nlm.nih.gov/pubmed/32393791 http://dx.doi.org/10.1038/s41419-020-2566-1

Ejemplares similares

Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
por: Cusimano, Antonella, et al.
Publicado: (2014)

The value measurement of emerging therapeutics in renal cell carcinoma: ASCO value framework and ESMO-MCBS
por: Ha, Hyerim, et al.
Publicado: (2022)

Prognostic Value of YTHDF2 in Clear Cell Renal Cell Carcinoma
por: Mu, Zhongyi, et al.
Publicado: (2020)

Prognostic Signatures and Therapeutic Value Based on the Notch Pathway in Renal Clear Cell Carcinoma
por: Li, Ziyao, et al.
Publicado: (2022)

PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma
por: Wang, Jianfeng, et al.
Publicado: (2021)

Diagnostic and prognostic value of CEP55 in clear cell renal cell carcinoma as determined by bioinformatics analysis
por: Zhou, Libin, et al.
Publicado: (2019)

Prognostic value of neutrophil extracellular trap signature in clear cell renal cell carcinoma
por: Li, Rong, et al.
Publicado: (2023)

SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/β‐catenin pathway
por: Chen, Wu, et al.
Publicado: (2021)

Multidetector CT Characteristics of Fumarate Hydratase-Deficient Renal Cell Carcinoma and Papillary Type II Renal Cell Carcinoma
por: Yang, Ling, et al.
Publicado: (2021)

Prevalence and prognostic value of FBXO11 expression in patients with clear cell renal cell carcinoma
por: Fan, Bo, et al.
Publicado: (2019)

HGF/c-Met Promote Renal Carcinoma Cancer Stem Cells Enrichment Through Upregulation of Cir-CCDC66
por: Yang, Juhong, et al.
Publicado: (2020)

Diagnostic value of circulating cell-free DNA for renal cell carcinoma: a meta-analysis
por: Li, Yong, et al.
Publicado: (2021)

Comprehensive Analysis of Transcriptional Expression of hsa-mir-21 Predicted Target Genes and Immune Characteristics in Kidney Renal Clear Cell Carcinoma
por: Xu, Da-Ming, et al.
Publicado: (2022)

The value of renal score in both determining surgical strategies and predicting complications for renal cell carcinoma: A systematic review and meta‐analysis
por: Shi, Naipeng, et al.
Publicado: (2020)

The expression and prognostic value of RNA binding proteins in clear cell renal cell carcinoma
por: Li, Can-Xuan, et al.
Publicado: (2020)

The Diagnostic and Immunotherapeutic Value of CD248 in Renal Cell Carcinoma
por: Zhang, Keying, et al.
Publicado: (2021)

GSDMs are potential therapeutic targets and prognostic biomarkers in clear cell renal cell carcinoma
por: Yao, Lei, et al.
Publicado: (2022)

The prognostic and predictive value of tumor infiltrating Macrophage and Neutrophil in patient with clear cell renal cell carcinoma: Tumor infiltrating lymphocytes in renal cell carcinoma
por: Xu, Weiqiang, et al.
Publicado: (2020)

Abnormal expression and the significant prognostic value of aquaporins in clear cell renal cell carcinoma
por: Li, Mingrui, et al.
Publicado: (2022)

Comprehensive exploration of the expression and prognostic value of AQPs in clear cell renal cell carcinoma
por: Wang, Huanrui, et al.
Publicado: (2022)

Potential prognostic and therapeutic value of ANXA8 in renal cell carcinoma: based on the comprehensive analysis of annexins family
por: Wang, Li-Hui, et al.
Publicado: (2023)

Diagnostic Value of Autoantibodies against Ezrin in Esophageal Squamous Cell Carcinoma
por: Li, Lan, et al.
Publicado: (2017)

Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma
por: Zhang, Chengcheng, et al.
Publicado: (2023)

Prognostic value of IKBIP in papillary renal cell carcinoma
por: Zhang, Huiling, et al.
Publicado: (2023)

RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma
por: Li, Diangeng, et al.
Publicado: (2021)

Prognostic value of copper transporter 1 expression in patients with clear cell renal cell carcinoma
por: Xia, Yu, et al.
Publicado: (2017)

Akt inhibitor SC66 promotes cell sensitivity to cisplatin in chemoresistant ovarian cancer cells through inhibition of COL11A1 expression
por: Wu, Yi-Hui, et al.
Publicado: (2019)

Value of radiomics in differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma
por: Li, Yajuan, et al.
Publicado: (2019)

Targeting Akt by SC66 triggers GSK-3β mediated apoptosis in colon cancer therapy
por: Liu, Yeying, et al.
Publicado: (2019)

The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma
por: Wang, Jin, et al.
Publicado: (2022)

Cystic renal cell carcinoma: a report of 67 cases including 4 cases with concurrent renal cell carcinoma
por: Chen, Shanwen, et al.
Publicado: (2014)

AKT Inhibitor SC66 Inhibits Proliferation and Induces Apoptosis in Human Glioblastoma Through Down-Regulating AKT/β-Catenin Pathway
por: Gao, Lun, et al.
Publicado: (2020)

Prognostic value of the ratio of maximum to minimum diameter of primary tumor in metastatic clear cell renal cell carcinoma
por: Shi, Hongzhe, et al.
Publicado: (2022)

Prognostic value of epithelial-mesenchymal transition markers in clear cell renal cell carcinoma
por: Xu, Hua, et al.
Publicado: (2020)

Key Prognostic Value of Lysosomal Protein Transmembrane 5 in Kidney Renal Clear Cell Carcinoma
por: Li, Bin, et al.
Publicado: (2022)

Prognostic Value of EZH2 Expression and Activity in Renal Cell Carcinoma: A Prospective Study
por: Liu, Li, et al.
Publicado: (2013)

Skewed T-helper (Th)1/2- and Th17/T regulatory-cell balances in patients with renal cell carcinoma
por: LI, LONG, et al.
Publicado: (2015)

Review of Value of CT Texture Analysis and Machine Learning in Differentiating Fat-Poor Renal Angiomyolipoma from Renal Cell Carcinoma
por: Zhang, Yuhan, et al.
Publicado: (2020)

High expression of Aldolase A predicts poor survival in patients with clear-cell renal cell carcinoma
por: Na, Ning, et al.
Publicado: (2017)

Crosstalk Between Metabolism and Immune Activity Reveals Four Subtypes With Therapeutic Implications in Clear Cell Renal Cell Carcinoma
por: Wang, Yi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ghb09rkrqddcpknbeu5mbllr2l