Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties

Missense-type mutant p53 plays a tumor-promoting role through gain-of-function (GOF) mechanism. In addition, the loss of wild-type TP53 through loss of heterozygosity (LOH) is widely found in cancer cells. However, malignant progression induced by cooperation of TP53 GOF mutation and LOH remains poo...

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Detalles Bibliográficos
Autores principales: Nakayama, Mizuho, Hong, Chang Pyo, Oshima, Hiroko, Sakai, Eri, Kim, Seong-Jin, Oshima, Masanobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214469/
https://www.ncbi.nlm.nih.gov/pubmed/32393735
http://dx.doi.org/10.1038/s41467-020-16245-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214469/
https://www.ncbi.nlm.nih.gov/pubmed/32393735
http://dx.doi.org/10.1038/s41467-020-16245-1

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