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TIGIT Blockade: A Multipronged Approach to Target the HIV Reservoir

During chronic human immunodeficiency virus type 1 (HIV-1) infection, upregulation of inhibitory molecules contributes to effector cell dysfunction and exhaustion. This, in combination with the ability of HIV-1 to reside dormant in cellular reservoirs and escape immune recognition, makes the pathway...

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Detalles Bibliográficos
Autores principales: Holder, Kayla A., Grant, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214612/
https://www.ncbi.nlm.nih.gov/pubmed/32432050
http://dx.doi.org/10.3389/fcimb.2020.00175