Iron Promotes Dihydroartemisinin Cytotoxicity via ROS Production and Blockade of Autophagic Flux via Lysosomal Damage in Osteosarcoma

Osteosarcoma cellular iron concentration is higher than that in normal bone cells and other cell types. High levels of cellular iron help catalyze the Fenton reaction to produce reactive oxygen species (ROS), which promotes cancer cell proliferation. Dihydroartemisinin (DHA), a classic anti-malarial...

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Detalles Bibliográficos
Autores principales: Shen, Ying, Zhang, Bin, Su, Yanwei, Badshah, Shaikh Atik, Wang, Xiaofei, Li, Xin, Xue, Yanru, Xie, Li, Wang, Zhe, Yang, Zhouqi, Zhang, Ge, Shang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214747/
https://www.ncbi.nlm.nih.gov/pubmed/32431605
http://dx.doi.org/10.3389/fphar.2020.00444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214747/
https://www.ncbi.nlm.nih.gov/pubmed/32431605
http://dx.doi.org/10.3389/fphar.2020.00444

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