Dexmedetomidine promotes breast cancer cell migration through Rab11-mediated secretion of exosomal TMPRSS2

BACKGROUND: Dexmedetomidine (DEX), a highly selective α2-adrenergic receptor agonist, has been reported to increase the malignancy of breast cancer cells in vitro and stimulate tumor growth in mice. Transmembrane protease serine 2 (TMPRSS2) demonstrates proteolytic activity, resulting in degradation...

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Detalles Bibliográficos
Autores principales: Chi, Meng, Shi, Xiaoding, Huo, Xing, Wu, Xiaohong, Zhang, Pinyi, Wang, Guonian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214880/
https://www.ncbi.nlm.nih.gov/pubmed/32411754
http://dx.doi.org/10.21037/atm.2020.04.28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214880/
https://www.ncbi.nlm.nih.gov/pubmed/32411754
http://dx.doi.org/10.21037/atm.2020.04.28

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