Enhanced pharmacokinetic performance of dapoxetine hydrochloride via the formulation of instantly-dissolving buccal films with acidic pH modifier and hydrophilic cyclodextrin: Factorial analysis, in vitro and in vivo assessment

Instantly dissolving buccal films have gained attention owing to their easy administration and capability to surmount the hepatic first pass effect of drugs. Dapoxetine hydrochloride (DPX) has a low oral bioavailability due to significant hepatic first pass metabolism. In addition, DPX is a weakly b...

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Detalles Bibliográficos
Autores principales: Aldawsari, Hibah M., Badr-Eldin, Shaimaa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215178/
https://www.ncbi.nlm.nih.gov/pubmed/32419956
http://dx.doi.org/10.1016/j.jare.2020.04.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215178/
https://www.ncbi.nlm.nih.gov/pubmed/32419956
http://dx.doi.org/10.1016/j.jare.2020.04.019

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