Structural Characterization of Carbonic Anhydrase VIII and Effects of Missense Single Nucleotide Variations to Protein Structure and Function

Human carbonic anhydrase 8 (CA-VIII) is an acatalytic isoform of the [Formula: see text]-CA family. Though the protein cannot hydrate CO(2), CA-VIII is essential for calcium (Ca(2+)) homeostasis within the body, and achieves this by allosterically inhibiting the binding of inositol 1,4,5-triphosphat...

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Detalles Bibliográficos
Autores principales: Sanyanga, Taremekedzwa Allan, Tastan Bishop, Özlem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215520/
https://www.ncbi.nlm.nih.gov/pubmed/32316137
http://dx.doi.org/10.3390/ijms21082764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215520/
https://www.ncbi.nlm.nih.gov/pubmed/32316137
http://dx.doi.org/10.3390/ijms21082764

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