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Structural Characterization of Carbonic Anhydrase VIII and Effects of Missense Single Nucleotide Variations to Protein Structure and Function
Human carbonic anhydrase 8 (CA-VIII) is an acatalytic isoform of the [Formula: see text]-CA family. Though the protein cannot hydrate CO(2), CA-VIII is essential for calcium (Ca(2+)) homeostasis within the body, and achieves this by allosterically inhibiting the binding of inositol 1,4,5-triphosphat...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215520/ https://www.ncbi.nlm.nih.gov/pubmed/32316137 http://dx.doi.org/10.3390/ijms21082764 |