Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice

Runx2 is required for chondrocyte proliferation and maturation. In the search of Runx2 target genes in chondrocytes, we found that Runx2 up-regulated the expression of hematopoietic cell kinase (Hck), which is a member of the Src tyrosine kinase family, in chondrocytes, that Hck expression was high...

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Detalles Bibliográficos
Autores principales: Matsuura, Viviane K. S. Kawata, Yoshida, Carolina Andrea, Komori, Hisato, Sakane, Chiharu, Yamana, Kei, Jiang, Qing, Komori, Toshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215647/
https://www.ncbi.nlm.nih.gov/pubmed/32290615
http://dx.doi.org/10.3390/ijms21082682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215647/
https://www.ncbi.nlm.nih.gov/pubmed/32290615
http://dx.doi.org/10.3390/ijms21082682

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