An Affibody Molecule Is Actively Transported into the Cerebrospinal Fluid via Binding to the Transferrin Receptor

The use of biotherapeutics for the treatment of diseases of the central nervous system (CNS) is typically impeded by insufficient transport across the blood–brain barrier. Here, we investigate a strategy to potentially increase the uptake into the CNS of an affibody molecule (Z(SYM73)) via binding t...

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Detalles Bibliográficos
Autores principales: Meister, Sebastian W., Hjelm, Linnea C., Dannemeyer, Melanie, Tegel, Hanna, Lindberg, Hanna, Ståhl, Stefan, Löfblom, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215652/
https://www.ncbi.nlm.nih.gov/pubmed/32340383
http://dx.doi.org/10.3390/ijms21082999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215652/
https://www.ncbi.nlm.nih.gov/pubmed/32340383
http://dx.doi.org/10.3390/ijms21082999

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