Knockout of ACTB and ACTG1 with CRISPR/Cas9(D10A) Technique Shows that Non-Muscle β and γ Actin Are Not Equal in Relation to Human Melanoma Cells’ Motility and Focal Adhesion Formation

Non-muscle actins have been studied for many decades; however, the reason for the existence of both isoforms is still unclear. Here we show, for the first time, a successful inactivation of the ACTB (CRISPR clones with inactivated ACTB, CR-ACTB) and ACTG1 (CRISPR clones with inactivated ACTG1, CR-AC...

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Detalles Bibliográficos
Autores principales: Malek, Natalia, Mrówczyńska, Ewa, Michrowska, Aleksandra, Mazurkiewicz, Ewa, Pavlyk, Iuliia, Mazur, Antonina Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216121/
https://www.ncbi.nlm.nih.gov/pubmed/32326615
http://dx.doi.org/10.3390/ijms21082746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216121/
https://www.ncbi.nlm.nih.gov/pubmed/32326615
http://dx.doi.org/10.3390/ijms21082746

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