Antimigraine Drug Avitriptan Is a Ligand and Agonist of Human Aryl Hydrocarbon Receptor that Induces CYP1A1 in Hepatic and Intestinal Cells

The efforts for therapeutic targeting of the aryl hydrocarbon receptor (AhR) have emerged in recent years. We investigated the effects of available antimigraine triptan drugs, having an indole core in their structure, on AhR signaling in human hepatic and intestinal cells. Activation of AhR in repor...

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Detalles Bibliográficos
Autores principales: Vyhlídalová, Barbora, Krasulová, Kristýna, Pečinková, Petra, Poulíková, Karolína, Vrzal, Radim, Andrysík, Zdeněk, Chandran, Aneesh, Mani, Sridhar, Dvorak, Zdenek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216230/
https://www.ncbi.nlm.nih.gov/pubmed/32316498
http://dx.doi.org/10.3390/ijms21082799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216230/
https://www.ncbi.nlm.nih.gov/pubmed/32316498
http://dx.doi.org/10.3390/ijms21082799

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