Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of Smo in Macrophage/Osteoclast Lineage Prevents Age-Related Bone Loss

The functional role of the Hedgehog (Hh)-signaling pathway has been widely investigated in bone physiology/development. Previous studies have, however, focused primarily on Hh functions in bone formation, while its roles in bone resorption have not been fully elucidated. Here, we found that cyclopam...

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Detalles Bibliográficos
Autores principales: Kohara, Yukihiro, Haraguchi, Ryuma, Kitazawa, Riko, Imai, Yuuki, Kitazawa, Sohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216259/
https://www.ncbi.nlm.nih.gov/pubmed/32326611
http://dx.doi.org/10.3390/ijms21082745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216259/
https://www.ncbi.nlm.nih.gov/pubmed/32326611
http://dx.doi.org/10.3390/ijms21082745

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