Detrimental role of sphingosine kinase 1 in kidney damage in DOCA-salt hypertensive model: evidence from knockout mice

BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive metabolite of sphingolipids and produced by sphingosine kinases (SphK1 and SphK2). SphK1/S1P pathway is implicated in the progression of chronic kidney disease. However, the role of SphK1/S1P pathway in renal injury in hypertension has not bee...

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Detalles Bibliográficos
Autores principales: Lyu, Bingqing, Wang, Weili, Ji, Xin-Ying, Ritter, Joseph K., Li, Ningjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216348/
https://www.ncbi.nlm.nih.gov/pubmed/32393187
http://dx.doi.org/10.1186/s12882-020-01815-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216348/
https://www.ncbi.nlm.nih.gov/pubmed/32393187
http://dx.doi.org/10.1186/s12882-020-01815-8

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