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1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain
Chronic pain can be the result of an underlying disease or condition, medical treatment, inflammation, or injury. The number of persons experiencing this type of pain is substantial, affecting upwards of 50 million adults in the United States. Pharmacotherapy of most of the severe chronic pain patie...
Autores principales: | Zhou, Yuan, Cai, Song, Gomez, Kimberly, Wijeratne, E. M. Kithsiri, Ji, Yingshi, Bellampalli, Shreya S., Luo, Shizhen, Moutal, Aubin, Gunatilaka, A. A. Leslie, Khanna, Rajesh |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216607/ https://www.ncbi.nlm.nih.gov/pubmed/32393368 http://dx.doi.org/10.1186/s13041-020-00616-2 |
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