Cargando…

Investigating the Causal Effect of Brain Expression of CCL2, NFKB1, MAPK14, TNFRSF1A, CXCL10 Genes on Multiple Sclerosis: A Two-Sample Mendelian Randomization Approach

Multiple Sclerosis (MS) exhibits considerable heterogeneity in phenotypic expression, course, prognosis and response to therapy. This suggests this disease involves multiple, as yet poorly understood, causal mechanisms. In this work we assessed the possible causal link between gene expression level...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fazia, Teresa, Nova, Andrea, Gentilini, Davide, Beecham, Ashley, Piras, Marialuisa, Saddi, Valeria, Ticca, Anna, Bitti, Pierpaolo, McCauley, Jacob L., Berzuini, Carlo, Bernardinelli, Luisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216783/ https://www.ncbi.nlm.nih.gov/pubmed/32432099 http://dx.doi.org/10.3389/fbioe.2020.00397

Ejemplares similares

Plasma Protein Levels Analysis in Multiple Sclerosis Sardinian Families Identified C9 and CYP24A1 as Candidate Biomarkers
por: Nova, Andrea, et al.
Publicado: (2022)

Homozygosity Haplotype and Whole-Exome Sequencing Analysis to Identify Potentially Functional Rare Variants Involved in Multiple Sclerosis among Sardinian Families
por: Fazia, Teresa, et al.
Publicado: (2021)

Heritability Estimation of Multiple Sclerosis Related Plasma Protein Levels in Sardinian Families with Immunochip Genotyping Data
por: Nova, Andrea, et al.
Publicado: (2022)

Multiple Sclerosis Heritability Estimation on Sardinian Ascertained Extended Families Using Bayesian Liability Threshold Model
por: Nova, Andrea, et al.
Publicado: (2023)

Acid sensing ion channel 2: A new potential player in the pathophysiology of multiple sclerosis
por: Fazia, Teresa, et al.
Publicado: (2019)

Mendelian randomisation analysis of clustered causal effects of body mass on cardiometabolic biomarkers
por: Conde, Susana, et al.
Publicado: (2018)

Association between the ACCN1 Gene and Multiple Sclerosis in Central East Sardinia
por: Bernardinelli, Luisa, et al.
Publicado: (2007)

Association between Protective and Deleterious HLA Alleles with Multiple Sclerosis in Central East Sardinia
por: Pastorino, Roberta, et al.
Publicado: (2009)

A Bayesian approach to Mendelian randomization with multiple pleiotropic variants
por: Berzuini, Carlo, et al.
Publicado: (2020)

Short-Term Meditation Training Fosters Mindfulness and Emotion Regulation: A Pilot Study
por: Fazia, Teresa, et al.
Publicado: (2020)

Boosting Psychological Well-Being through a Social Mindfulness-Based Intervention in the General Population
por: Fazia, Teresa, et al.
Publicado: (2020)

Mindfulness meditation training in an occupational setting: Effects of a 12-weeks mindfulness-based intervention on wellbeing
por: Fazia, Teresa, et al.
Publicado: (2021)

Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis
por: Chen, Jie, et al.
Publicado: (2022)

A Pipeline for Phasing and Genotype Imputation on Mixed Human Data (Parents-Offspring Trios and Unrelated Subjects) by Reviewing Current Methods and Software
por: Baldrighi, Giulia Nicole, et al.
Publicado: (2022)

Posterior Reversible Encephalopathy Syndrome with Bilateral Independent Epileptic Foci Precipitated By Guillain-Barrè Syndrome
por: Rossi, Rosario, et al.
Publicado: (2016)

NGS analysis in Marfan syndrome spectrum: Combination of rare and common genetic variants to improve genotype-phenotype correlation analysis
por: Gentilini, Davide, et al.
Publicado: (2019)

Broadening the phenotype of TARDBP mutations: the TARDBP Ala382Thr mutation and Parkinson’s disease in Sardinia
por: Quadri, Marialuisa, et al.
Publicado: (2011)

Gene expression pattern of CCL2, CCL3, and CXCL8 in patients with bipolar disorder
por: Ghoryani, Mohsen, et al.
Publicado: (2019)

Integrative analysis of Mendelian randomization and Bayesian colocalization highlights four genes with putative BMI-mediated causal pathways to diabetes
por: Liu, Qian, et al.
Publicado: (2020)

Overlapping-sample Mendelian randomisation with multiple exposures: a Bayesian approach
por: Zou, Linyi, et al.
Publicado: (2020)

Bayesian mendelian randomization with study heterogeneity and data partitioning for large studies
por: Zou, Linyi, et al.
Publicado: (2022)

Higher Expression of CCL2, CCL4, CCL5, CCL21, and CXCL8 Chemokines in the Skin Associated with Parasite Density in Canine Visceral Leishmaniasis
por: Menezes-Souza, Daniel, et al.
Publicado: (2012)

Fine-Mapping Array Design for Multi-Ethnic Studies of Multiple Sclerosis
por: Beecham, Ashley H., et al.
Publicado: (2019)

TNFα Causes a Shift in Gene Expression of TNFRSF1A and TNFRSF1B Isoforms
por: Perik-Zavodskaia, Olga, et al.
Publicado: (2023)

Novel inhibitors are cytotoxic for myeloma cells with NFkB inducing kinase-dependent activation of NFkB
por: Demchenko, Yulia N., et al.
Publicado: (2014)

CCL2 and CXCL10 are associated with poor outcome after intracerebral hemorrhage
por: Landreneau, Margaret J., et al.
Publicado: (2018)

Increased CCL24 and CXCL7 levels in the cerebrospinal fluid of patients with neurosyphilis
por: Li, Xin‐Xin, et al.
Publicado: (2020)

Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells
por: Dickhout, Annemiek, et al.
Publicado: (2021)

Epigenome Wide Association and Stochastic Epigenetic Mutation Analysis on Cord Blood of Preterm Birth
por: Spada, Elena, et al.
Publicado: (2020)

NFKB1 and Cancer: Friend or Foe?
por: Concetti, Julia, et al.
Publicado: (2018)

NFkB Pathway and Hodgkin Lymphoma
por: Jardin, Fabrice
Publicado: (2022)

A Study of IFN-α-Induced Chemokines CCL2, CXCL10 and CCL19 in Patients with Systemic Lupus Erythematosu
por: Geneva-Popova, Mariela Gencheva, et al.
Publicado: (2022)

Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells
por: Pharoah, Daniel S, et al.
Publicado: (2006)

Murine Placental Erythroid Cells Are Mainly Represented by CD45(+) Immunosuppressive Erythroid Cells and Secrete CXCL1, CCL2, CCL3 and CCL4 Chemokines
por: Nazarov, Kirill, et al.
Publicado: (2023)

SLC/CCL21-mediated anti-tumor responses require IFNγ, MIG/CXCL9 and IP-10/CXCL10
por: Sharma, Sherven, et al.
Publicado: (2003)

CCL3 and MMP-9 are induced by TL1A during death receptor 3 (TNFRSF25)-dependent osteoclast function and systemic bone loss
por: Collins, Fraser L., et al.
Publicado: (2017)

Myc suppression of Nfkb2 accelerates lymphomagenesis
por: Keller, Ulrich, et al.
Publicado: (2010)

Nfkb1/p50 and mammalian aging
por: Yamini, Bakhtiar
Publicado: (2015)

Altered mRNA Expression of NFKB1 and NFKB2 Genes in Penile Lichen Sclerosus, Penile Cancer and Zoon Balanitis
por: Wierzbicki, Piotr M., et al.
Publicado: (2022)

On the TRAIL of Better Therapies: Understanding TNFRSF Structure-Function
por: Vanamee, Éva S., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qdvkcoj1vvp315t59kv6uie9jg