Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine

Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high personal and societal burden. Exposure to toxic particles and gases, including cigarette smoke, is the main risk factor for COPD. Together with smoking cessation, current treatment strategies of COPD aim to improv...

Descripción completa

Detalles Bibliográficos
Autores principales: Brandsma, Corry‐Anke, Van den Berge, Maarten, Hackett, Tillie‐Louise, Brusselle, Guy, Timens, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216938/
https://www.ncbi.nlm.nih.gov/pubmed/31691283
http://dx.doi.org/10.1002/path.5364
_version_ 1783532513648443392
author Brandsma, Corry‐Anke
Van den Berge, Maarten
Hackett, Tillie‐Louise
Brusselle, Guy
Timens, Wim
author_facet Brandsma, Corry‐Anke
Van den Berge, Maarten
Hackett, Tillie‐Louise
Brusselle, Guy
Timens, Wim
author_sort Brandsma, Corry‐Anke
collection PubMed
description Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high personal and societal burden. Exposure to toxic particles and gases, including cigarette smoke, is the main risk factor for COPD. Together with smoking cessation, current treatment strategies of COPD aim to improve symptoms and prevent exacerbations, but there is no disease‐modifying treatment. The biggest drawback of today's COPD treatment regimen is the ‘one size fits all’ pharmacological intervention, mainly based on disease severity and symptoms and not the individual's disease pathology. To halt the worrying increase in the burden of COPD, disease management needs to be advanced with a focus on personalized treatment. The main pathological feature of COPD includes a chronic and abnormal inflammatory response within the lungs, which results in airway and alveolar changes in the lung as reflected by (small) airways disease and emphysema. Here we discuss recent developments related to the abnormal inflammatory response, ECM and age‐related changes, structural changes in the small airways and the role of sex‐related differences, which are all relevant to explain the individual differences in the disease pathology of COPD and improve disease endotyping. Furthermore, we will discuss the most recent developments of new treatment strategies using biologicals to target specific pathological features or disease endotypes of COPD. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
format Online
Article
Text
id pubmed-7216938
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher John Wiley & Sons, Ltd
record_format MEDLINE/PubMed
spelling pubmed-72169382020-05-13 Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine Brandsma, Corry‐Anke Van den Berge, Maarten Hackett, Tillie‐Louise Brusselle, Guy Timens, Wim J Pathol Invited Reviews Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high personal and societal burden. Exposure to toxic particles and gases, including cigarette smoke, is the main risk factor for COPD. Together with smoking cessation, current treatment strategies of COPD aim to improve symptoms and prevent exacerbations, but there is no disease‐modifying treatment. The biggest drawback of today's COPD treatment regimen is the ‘one size fits all’ pharmacological intervention, mainly based on disease severity and symptoms and not the individual's disease pathology. To halt the worrying increase in the burden of COPD, disease management needs to be advanced with a focus on personalized treatment. The main pathological feature of COPD includes a chronic and abnormal inflammatory response within the lungs, which results in airway and alveolar changes in the lung as reflected by (small) airways disease and emphysema. Here we discuss recent developments related to the abnormal inflammatory response, ECM and age‐related changes, structural changes in the small airways and the role of sex‐related differences, which are all relevant to explain the individual differences in the disease pathology of COPD and improve disease endotyping. Furthermore, we will discuss the most recent developments of new treatment strategies using biologicals to target specific pathological features or disease endotypes of COPD. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. John Wiley & Sons, Ltd 2019-12-03 2020-04 /pmc/articles/PMC7216938/ /pubmed/31691283 http://dx.doi.org/10.1002/path.5364 Text en © 2020 Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Invited Reviews
Brandsma, Corry‐Anke
Van den Berge, Maarten
Hackett, Tillie‐Louise
Brusselle, Guy
Timens, Wim
Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine
title Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine
title_full Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine
title_fullStr Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine
title_full_unstemmed Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine
title_short Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine
title_sort recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine
topic Invited Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216938/
https://www.ncbi.nlm.nih.gov/pubmed/31691283
http://dx.doi.org/10.1002/path.5364
work_keys_str_mv AT brandsmacorryanke recentadvancesinchronicobstructivepulmonarydiseasepathogenesisfromdiseasemechanismstoprecisionmedicine
AT vandenbergemaarten recentadvancesinchronicobstructivepulmonarydiseasepathogenesisfromdiseasemechanismstoprecisionmedicine
AT hacketttillielouise recentadvancesinchronicobstructivepulmonarydiseasepathogenesisfromdiseasemechanismstoprecisionmedicine
AT brusselleguy recentadvancesinchronicobstructivepulmonarydiseasepathogenesisfromdiseasemechanismstoprecisionmedicine
AT timenswim recentadvancesinchronicobstructivepulmonarydiseasepathogenesisfromdiseasemechanismstoprecisionmedicine