Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high personal and societal burden. Exposure to toxic particles and gases, including cigarette smoke, is the main risk factor for COPD. Together with smoking cessation, current treatment strategies of COPD aim to improv...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216938/ https://www.ncbi.nlm.nih.gov/pubmed/31691283 http://dx.doi.org/10.1002/path.5364 |
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author | Brandsma, Corry‐Anke Van den Berge, Maarten Hackett, Tillie‐Louise Brusselle, Guy Timens, Wim |
author_facet | Brandsma, Corry‐Anke Van den Berge, Maarten Hackett, Tillie‐Louise Brusselle, Guy Timens, Wim |
author_sort | Brandsma, Corry‐Anke |
collection | PubMed |
description | Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high personal and societal burden. Exposure to toxic particles and gases, including cigarette smoke, is the main risk factor for COPD. Together with smoking cessation, current treatment strategies of COPD aim to improve symptoms and prevent exacerbations, but there is no disease‐modifying treatment. The biggest drawback of today's COPD treatment regimen is the ‘one size fits all’ pharmacological intervention, mainly based on disease severity and symptoms and not the individual's disease pathology. To halt the worrying increase in the burden of COPD, disease management needs to be advanced with a focus on personalized treatment. The main pathological feature of COPD includes a chronic and abnormal inflammatory response within the lungs, which results in airway and alveolar changes in the lung as reflected by (small) airways disease and emphysema. Here we discuss recent developments related to the abnormal inflammatory response, ECM and age‐related changes, structural changes in the small airways and the role of sex‐related differences, which are all relevant to explain the individual differences in the disease pathology of COPD and improve disease endotyping. Furthermore, we will discuss the most recent developments of new treatment strategies using biologicals to target specific pathological features or disease endotypes of COPD. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. |
format | Online Article Text |
id | pubmed-7216938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-72169382020-05-13 Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine Brandsma, Corry‐Anke Van den Berge, Maarten Hackett, Tillie‐Louise Brusselle, Guy Timens, Wim J Pathol Invited Reviews Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high personal and societal burden. Exposure to toxic particles and gases, including cigarette smoke, is the main risk factor for COPD. Together with smoking cessation, current treatment strategies of COPD aim to improve symptoms and prevent exacerbations, but there is no disease‐modifying treatment. The biggest drawback of today's COPD treatment regimen is the ‘one size fits all’ pharmacological intervention, mainly based on disease severity and symptoms and not the individual's disease pathology. To halt the worrying increase in the burden of COPD, disease management needs to be advanced with a focus on personalized treatment. The main pathological feature of COPD includes a chronic and abnormal inflammatory response within the lungs, which results in airway and alveolar changes in the lung as reflected by (small) airways disease and emphysema. Here we discuss recent developments related to the abnormal inflammatory response, ECM and age‐related changes, structural changes in the small airways and the role of sex‐related differences, which are all relevant to explain the individual differences in the disease pathology of COPD and improve disease endotyping. Furthermore, we will discuss the most recent developments of new treatment strategies using biologicals to target specific pathological features or disease endotypes of COPD. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. John Wiley & Sons, Ltd 2019-12-03 2020-04 /pmc/articles/PMC7216938/ /pubmed/31691283 http://dx.doi.org/10.1002/path.5364 Text en © 2020 Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Invited Reviews Brandsma, Corry‐Anke Van den Berge, Maarten Hackett, Tillie‐Louise Brusselle, Guy Timens, Wim Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine |
title | Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine |
title_full | Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine |
title_fullStr | Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine |
title_full_unstemmed | Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine |
title_short | Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine |
title_sort | recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine |
topic | Invited Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216938/ https://www.ncbi.nlm.nih.gov/pubmed/31691283 http://dx.doi.org/10.1002/path.5364 |
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