Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development

Immunotherapy using immune checkpoint inhibitors (ICIs) induces durable responses in many metastatic cancers. Metastatic uveal melanoma (mUM), typically occurring in the liver, is one of the most refractory tumours to ICIs and has dismal outcomes. Monosomy 3 (M3), polysomy 8q, and BAP1 loss in prima...

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Detalles Bibliográficos
Autores principales: Figueiredo, Carlos R, Kalirai, Helen, Sacco, Joseph J, Azevedo, Ricardo A, Duckworth, Andrew, Slupsky, Joseph R, Coulson, Judy M, Coupland, Sarah E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2020
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216965/
https://www.ncbi.nlm.nih.gov/pubmed/31960425
http://dx.doi.org/10.1002/path.5384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216965/
https://www.ncbi.nlm.nih.gov/pubmed/31960425
http://dx.doi.org/10.1002/path.5384

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