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Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development
Immunotherapy using immune checkpoint inhibitors (ICIs) induces durable responses in many metastatic cancers. Metastatic uveal melanoma (mUM), typically occurring in the liver, is one of the most refractory tumours to ICIs and has dismal outcomes. Monosomy 3 (M3), polysomy 8q, and BAP1 loss in prima...
Autores principales: | Figueiredo, Carlos R, Kalirai, Helen, Sacco, Joseph J, Azevedo, Ricardo A, Duckworth, Andrew, Slupsky, Joseph R, Coulson, Judy M, Coupland, Sarah E |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216965/ https://www.ncbi.nlm.nih.gov/pubmed/31960425 http://dx.doi.org/10.1002/path.5384 |
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