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Total Synthesis of a Mycolic Acid from Mycobacterium tuberculosis

In Mycobacterium tuberculosis, mycolic acids and their glycerol, glucose, and trehalose esters (“cord factor”) form the main part of the mycomembrane. Despite their first isolation almost a century ago, full stereochemical evaluation is lacking, as is a scalable synthesis required for accurate immun...

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Detalles Bibliográficos
Autores principales: Tahiri, Nabil, Fodran, Peter, Jayaraman, Dhineshkumar, Buter, Jeffrey, Witte, Martin D., Ocampo, Tonatiuh A., Moody, D. Branch, Van Rhijn, Ildiko, Minnaard, Adriaan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216993/
https://www.ncbi.nlm.nih.gov/pubmed/32067294
http://dx.doi.org/10.1002/anie.202000523